Palacio de los Medina Rosales is a Renaissance palace constructed in the second half of the 16th century by Juan Vallejo in Cadiñanos, in the Merindades region of Burgos. The colossal structure consists of two towers united by a central body adorned with elaborate Plateresque architectural details. Originally featuring towers at each corner with square floor plans, the palace today survives in a ruined state with one complete tower and portions of another remaining along with fragments of the decorated facade. Designated as a Cultural Property of Interest (BIC) in 1991, it exemplifies 16th-century noble architecture despite its current lamentable preservation.